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Cat. Number:

bs-5871R-PE

Quantity size:

100ul

Concentration:

1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Kallikrein 8 (hK8), also known as neuropsin, brain serine protease 1 (BSP1), tumor associated differentially expressed gene 14 (TADG14), PRSS19, HNP and ovasin, is a trypsin like serine protease. Originally described from mouse brain, KLK8 was implicated in neural plasticity and learning. Kallikrein 8 is thought to be involved in neurite outgrowth and fasciculation during nervous system development. Kallikrein 8 is induced in neurite injury, and Kallikrein 8 has been shown to be elevated in the hippocampus on Alzheimer’s patients’ brains. Animal models of autoimmune encephalomyelitis (EAE) show elevated Kallikrein 8 production. Kallikrein 8 null mice have aberrant synapses in their hippocampus, compared to wild type mice, and are predisposed to seizures. Kallikrein 8 is thought to regulate the early phase of long-term potentiation (LTP), possibly by cleaving fibronectin and other substrates. Kallikrein 8 is also found in the uterus, where it is hormonally regulated. Cervical cancer cell lines express high levels of Kallikrein 8, and it may be useful as a tumor marker. Kallikrein 8 is not limited to the brain and uterus, as many tissues and cell lines make the protein. Endogenous inhibitors include serine protease inhibitor 3 and protein C inhibitor, although Kallikrein 8 can be found complexed to a number of different protease inhibitors.

Also known as:

Kallikrein-8; Ovasin; Serine protease TADG 14; Tumor associated differentially expressed gene 14 protein; Brain serine protease 1; BSP1; hK8; HNP; HPN; Kallikrein 8 (neuropsin/ovasin); Kallikrein related peptidase 8; Kallikrein8; KLK 8; KLK8; KLK-8; KLK8 protein type 1; KLK8 protein type 2; Neuropsin; neuropsin type 1; Neuropsin type 1, included; Neuropsin type 2; Neuropsin type 2, included; Neuropsin, mouse, homolog of; NP; NRPN; Protease serine 19; PRSS 19; PRSS19; Serine protease 19; Serine protease kallikrein; Serine protease kallikrein/ovasin/neuropsin; Serine protease TADG14; TADG 14; TADG14; Tumor associated differentially expressed gene 14.

Specificity:

Storage:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Application:

Excitation spectrum: 496nm,564nm
Emission spectrum: 578nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.