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Rabbit
Anti-PRAK/Gold
Cat. Number:
bs-4137R-Gold
Quantity size:
100ul
10nm
Concentration:
0.4mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The serine/threonine kinase PRAK is activated in response to cellular stress and proinflammatory cytokines, through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38 alpha, and MAPK11/p38 beta. PRAK has been reported to have a putative tumor suppressor function by mediating senescence upon activation by p38 in response to oncogenic ras. It is thought that phosphorylation of p53 by PRAK following activation of p38 MAPK by ras plays an important role in ras induced senescence and tumor suppression.
Also known as:
MAP kinase-activated protein kinase 5; PRAK; MAPKAP kinase 5; MAPKAPK5; MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; p38-regulated/activated protein kinase.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human MAPKAPK5/PRAK.
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Predicted Molecular Weight: 52kDa.
Storage:
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.