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Catalog Number:

bs-0698P

Species:

human

Activity:

Not tested

Purification:

1

Storage:

Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background:

IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.