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Rabbit
Anti-JNK3/MAPK10/Gold
Cat. Number:
bs-2997R-Gold
Quantity size:
100ul
10nm
Concentration:
0.4mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Also known as:
c Jun kinase 3;
c-Jun N-terminal kinase 3;
cJun N terminal kinase 3;
FLJ12099;
FLJ33785;
JNK3 alpha protein kinase;
JNK3;
JNK3A;
MAP kinase 10;
MAP kinase;
MAP kinase p49 3F12;
MAPK 10;
Mapk10;
MGC50974;
mitogen activated protein kinase 10;
Mitogen-activated protein kinase 10;
MK10_HUMAN;
p493F12;
p54bSAPK;
PRKM10;
protein kinase mitogen activated 10;
SAPK1b;
Stress activated protein kinase 1b;
stress activated protein kinase beta;
Stress activated protein kinase JNK3;
Stress-activated protein kinase JNK3.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
●
Immunogen: KLH conjugated synthetic peptide derived from human JNK3/MAPK10.
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Predicted Molecular Weight: 30-51kDa.
Storage:
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.