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Rabbit
Anti-LC3B/Gold
Cat. Number:
bs-2912R-Gold
Quantity size:
100ul
35nm
Concentration:
0.4mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.
Also known as:
LC3II; LC-3Ⅱ; ATG8F;
Autophagy related protein LC3 B;
Autophagy related ubiquitin like modifier LC3 B;
Autophagy-related protein LC3 B;
Autophagy-related ubiquitin-like modifier LC3 B;
LC3B;
MAP1 light chain 3 like protein 2;
MAP1 light chain 3-like protein 2;
MAP1A/1B light chain 3 B;
MAP1A/1BLC3;
MAP1A/MAP1B LC3 B;
MAP1A/MAP1B light chain 3 B;
MAP1ALC3;
MAP1LC3B a;
MAP1LC3B;
Microtubule associated protein 1 light chain 3 beta;
Microtubule associated proteins 1A/1B light chain 3B;
Microtubule-associated protein 1 light chain 3 beta;
Microtubule-associated proteins 1A/1B light chain 3B;
MLP3B_HUMAN
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with:
(predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human LC3A/B.
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Predicted Molecular Weight: 13kDa.
Storage:
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.