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Rabbit
Anti-Phospho-Doublecortin (Ser128)/Gold
Cat. Number:
bs-3113R-Gold
Quantity size:
100ul
15nm
Concentration:
0.4mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Also known as:
Doublecortin (phospho S128);
p-Doublecortin (phospho S128);
DBCN;
DBCN;
Dbct;
Dbct;
DC;
DC;
DCX;
DCX;
DCX_HUMAN;
Doublecortex;
Doublecortex;
Doublin;
FLJ51296;
Lis X;
Lis X;
Lis-X;
Lissencephalin X;
Lissencephalin X;
Lissencephalin-X;
Lissencephaly X linked;
Lissencephaly X linked;
Lissencephaly X linked doublecortin;
Lissencephaly X linked doublecortin;
LISX;
LISX;
Neuronal migration protein doublecortin;
OTTHUMP00000023859;
OTTHUMP00000023860;
OTTHUMP00000216315;
OTTHUMP00000216316;
SCLH;
SCLH;
XLIS;
XLIS.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
●
Immunogen: KLH conjugated Synthesised phosphopeptide derived from human Doublecortin around the phosphorylation site of Ser128.
●
Predicted Molecular Weight: 40kDa.
Storage:
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.