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Rabbit
Anti-Pro-neuregulin-1, membrane-bound isoform/AP
Cat. Number:
bs-1817R-AP
Quantity size:
100ul
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
NRG1 (Neuregulin 1) is a ligand for ERBB3 and ERBB4 tyrosine kinase receptors. NRG1 concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. There are multiple isoforms of NRG1, the type I isoforms (isoforms 1-8) have an Ig domain and a glycosylation domain. There are 10 known isoforms in total which perform distinct tissue-specific functions. Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in nonneuronal organs, whereas isoform 5 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain.
Also known as:
Acetylcholine receptor-inducing activity;
ARIA;
Breast cancer cell differentiation factor p45;
CHICK, homolog of;
GGF;
GGF2;
Glial growth factor;
Heregulin;
heregulin, alpha (45kD, ERBB2 p185-activator);
heregulin, alpha;
HGL;
HRG;
HRG1;
HRGA;
MST131;
NDF;
Neu differentiation factor;
neuregulin 1 type IV beta 1a;
neuregulin 1 type IV beta 3;
NRG 1;
nrg1;
NRG1 beta;
NRG1_HUMAN;
Pro-neuregulin-1, membrane-bound isoform;
Pro-NRG1;
Sensory and motor neuron-derived factor;
SMDF; NRG1_MOUSE.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
●
Immunogen: KLH conjugated synthetic peptide derived from mouse HRG Beta1.
●
Predicted Molecular Weight: 71kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.