HSPA8 | HSC70 Rabbit pAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bs-5117R

农牧业/家禽抗体

HSPA8 | HSC70 Rabbit pAb

热休克蛋白71抗体

HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71; 2410008N15Rik; Hsc73; HSP7C_HUMAN; HSPA8; Heat shock 70 kDa protein 8; Heat shock protein family A member 8; Lipopolysaccharide-associated protein 1 (LAP-1 | LPS-associated protein 1); 3.6.4.10; HSP7C_MOUSE; HSP7C_RAT; heat shock protein family A (Hsp70) member 8; heat shock 70kD protein 8; heat shock 70kDa protein 8

Rabbit

KLH conjugated synthetic peptide derived from human HSP71: 501-600/646

IgG

Liquid

affinity purified by Protein A

Polyclonal

71 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

HSPA8

Heat shock cognate 71 kDa protein

Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7 (By similarity). Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation.

Cytoplasm. Melanosome.

Ubiquitous.

Phosphorylated upon DNA damage, probably by ATM or ATR. ISGylated.

Belongs to the heat shock protein 70 family.

Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.