GPER1 | GPR30 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bs-20643R

宠物抗体

GPER1 | GPR30 Rabbit pAb

G蛋白偶联受体30抗体

CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPR30; LERGU; LERGU2; LyGPR; mER; 6330420K13Rik; Ceprl; GPR41; GPER1_HUMAN; GPER1; Chemoattractant receptor-like 2; Flow-induced endothelial G-protein coupled receptor 1 (FEG-1); G protein-coupled estrogen receptor 1; G-protein coupled receptor 30; IL8-related receptor DRY12; Lymphocyte-derived G-protein coupled receptor (LYGPR); Membrane estrogen receptor (mER); GPER1_MOUSE; GPER1_RAT; G-protein coupled receptor 41; G protein-coupled receptor 30

Rabbit

KLH conjugated synthetic peptide derived from human GPR30: 251-350/375

IgG

Liquid

affinity purified by Protein A

Polyclonal

42 kDa

53 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GPR30是一种膜性雌激素蛋白受体又称非基因型雌激素膜性受体GPR30。GPR30受体广泛表达于海马、下丘脑、子宫、卵巢、乳腺、骨和心血管等全身多个系统、器官和组织,在细胞内主要定位于细胞膜、内质网、线粒体和高尔基体。 GPER与雌激素结合, ERK、PI3K/AKT)、 cAMP等第二信使途径发挥快速非基因效应,在神经系统、生殖系统、运动系统和心血管系统中发挥重要的生理作用。

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]

GPER1

G-protein coupled estrogen receptor 1

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Protein has been detected in the cell membrane, endoplasmic reticulum and Golgi apparatus. It is currently unclear whether this is a cell surface or intracellular receptor.

Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.

Belongs to the G-protein coupled receptor 1 family.

Receptor for estrogen.