Podoplanin Recombinant Rabbit mAb (一抗) | Bioss

bsm-52936R

重组兔单抗、mIHC精品抗体

Podoplanin Recombinant Rabbit mAb

平足蛋白/淋巴管内皮细胞蛋白重组兔单抗

AGGRUS; D2-40; GP36; GP40; Gp38; HT1A-1; OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A; E11; OTS-8; RANDAM-2; T1-alpha; T1alpha; RTI140; RTI40; PDPN_HUMAN; PDPN; Glycoprotein 36 (Gp36); PA2.26 antigen; T1-alpha (T1A); PDPN_MOUSE; Glycoprotein 38 (Gp38); Transmembrane glycoprotein E11 (E11); PDPN_RAT; E11 antigen epitope; Type I cell 40 kDa protein; podoplanin; lung type I cell membrane associated glycoprotein

Rabbit

A synthesized peptide derived from human Podoplanin: 23-85

IgG

Liquid

affinity purified by Protein A

Recombinant

3C3

15 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Podoplanin Protein是一种肾小球足状突细胞膜粘蛋白，目前已成为一种新的淋巴管内皮标记物蛋白，在少数小静脉上也有表达。 podoplanin Protein是淋巴管内皮高度敏感且特异性的标记物，作为肿瘤细胞的血小板聚集介导因子而发挥作用，能促进肿瘤细胞迁移及增加肿瘤细胞侵袭力。

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PDPN

Podoplanin

Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.

Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.

Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. The N-terminus is blocked.

Belongs to the podoplanin family.

May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.