StAR Rabbit pAb (一抗) | Bioss

bs-3570R

宠物抗体、农牧业/家禽抗体

StAR Rabbit pAb

类固醇激素合成急性调节蛋白抗体

STARD1; D8Ertd419e; STAR_HUMAN; STAR; START domain-containing protein 1 (StARD1); STAR_MOUSE; Luteinizing hormone-induced protein; STAR_RAT; steroidogenic acute regulatory protein; steroidogenic acute regulator; StAR related lipid transfer (START) domain containing 1

Rabbit

KLH conjugated synthetic peptide derived from human StAR/StARD1: 101-200/285

IgG

Liquid

affinity purified by Protein A

Polyclonal

32 kDa

28 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008].

STAR

Steroidogenic acute regulatory protein, mitochondrial

May interact with TSPO.

Mitochondrion.

Defects in STAR are the cause of adrenal hyperplasia type 1 (AH1) [MIM:201710]. The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma rennin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.

Contains 1 START domain.

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.