P Glycoprotein Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-54782R

重组兔单抗、离子通道抗体、mIHC精品抗体

P Glycoprotein Recombinant Rabbit mAb

P-糖蛋白重组兔单克隆抗体

ABC20; CD243; CLCS; ENPAT; GP170; MDR1; P-GP; PGY1; p-170; Abcb1; Mdr1b; Pgy-1; mdr; MDR1_HUMAN; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; MDR1B_MOUSE; Abcb1b; ATP-binding cassette sub-family B member 1B; Multidrug resistance protein 1B; Pgy1-1; ATP binding cassette subfamily B member 1; colchicin sensitivity; ATP-binding cassette, sub-family B (MDR/TAP), member 1; P-glycoprotein

Rabbit

Recombinant Human P-glycoprotein 1 protein

IgG

Liquid

affinity purified by Protein A

Recombinant

2C11

141 kDa

140-180 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信号传导（Signaling Intermediates）

bs-1468P is one synthetic peptide derived from human MDR1.
P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

ABCB1

ATP-dependent translocase ABCB1

Interacts with PSMB5.

Cell membrane; Multi-pass membrane protein.

Expressed in liver, kidney, small intestine and brain.

Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Subunit : Interacts with PSMB5.