HSP70 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-52241R

重组兔单抗、mIHC精品抗体

HSP70 Recombinant Rabbit mAb

热休克蛋白-70重组兔单抗

HSP70-1; HSPA1; HEL-S-103; HSP70; HSP70-1A; HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; Hsp70-3; Hsp70.3; hsp68; hsp70A1; Hspa1a; Hspa2; HS71A_BOVIN; Heat shock 70 kDa protein 1 (HSP70.1); HS71A_HUMAN; Heat shock 70 kDa protein 1 (HSP70-1 | HSP70.1); Heat shock protein family A member 1A; HSX70; HS71B_HUMAN; HSPA1B; Heat shock 70 kDa protein 2 (HSP70-2 | HSP70.2); Heat shock protein family A member 1B; HS71B_MOUSE; Hcp70.1; HS71A_MOUSE; Heat shock 70 kDa protein 3 (HSP70.3); HSP71_RAT; heat shock protein family A (Hsp70) member 1A; heat shock 70kD protein 1A; heat shock 70kDa protein 1A

Rabbit

A synthesized peptide derived from human Hsp70: 400-641

IgG

Liquid

affinity purified by Protein A

Recombinant

2G2

70 kDa

68 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HSP-70是细胞受应激原刺激后诱导产生的一组应激蛋白，与肿瘤发生、增殖及分化有关。环境和病生理性应激原均可导致肌体合成一组应急蛋白既热休克蛋白。许多热休克蛋白，包括HSP70家族成员，均参与蛋白的变性-复性、折叠-解折叠、运输-易位、活化-非活化和分泌等过程。 HSP70与类固醇受体、肌动蛋白、P53等蛋白密切相关。HSP70还参与热应激原、细胞毒药物和其他损伤所引起的应急反应，对机体起一定的保护作用。

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].

HSPA1A

Heat shock 70 kDa protein 1A

Component of the CatSper complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7. Interacts with CHCHD3.

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

HSPA1B is testis-specific.

Belongs to the heat shock protein 70 family.

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.