ADAM17 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-52009R

重组兔单抗

ADAM17 Recombinant Rabbit mAb

ADAM17重组兔单抗

ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE; ADA17_HUMAN; ADAM17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; 3.4.24.86; ADA17_MOUSE; ADA17_RAT; ADAM metallopeptidase domain 17; tumor necrosis factor, alpha, converting enzyme; cartilage snake venom-like protease; TNF-alpha convertase enzyme; a disintegrin and metalloproteinase 17

Rabbit

A synthesized peptide derived from human ADAM 17: 750-784

IgG

Liquid

affinity purified by Protein A

Recombinant

9E7

93 kDa

100-120 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ADAM17

Disintegrin and metalloproteinase domain-containing protein 17

Interacts with MAD2L1, MAPK14 and MUC1.

Membrane.

Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).