CYBB | NOX2 Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-52603R

重组兔单抗

CYBB | NOX2 Recombinant Rabbit mAb

NOX2重组兔单抗

NOX2; AMCBX2; CGD; CGDX; GP91-1; GP91-PHOX; GP91PHOX; IMD34; p91-PHOX; CGD91-phox; Cyd; CY24B_BOVIN; CYBB; Cytochrome b(558) subunit beta (Cytochrome b558 subunit beta); Cytochrome b-245 heavy chain; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome; 1.6.3.-; CY24B_HUMAN; Superoxide-generating NADPH oxidase heavy chain subunit; CY24B_MOUSE; cytochrome b-245 beta chain; chronic granulomatous disease; cytochrome b-245, beta polypeptide; NADPH oxidase 2; Cytochrome b558 subunit beta

Rabbit

A synthesized peptide derived from human NOX2: 142-204/570

IgG

Liquid

affinity purified by Protein A

Recombinant

9B12

65 kDa

55 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NOX2也是一个很重要的产生氧自由基的酶。主要存在于甲状腺,前列腺，唾液腺和直肠粘膜中。

NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.

CYBB

Cytochrome b-245 heavy chain

Membrane.

Glycosylated.

Defects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:306400]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.

Contains 1 FAD-binding FR-type domain.
Contains 1 ferric oxidoreductase domain.

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.