Aquaporin 1 is a 28kD integral membrane protein which was originally identified in red blood cells and renal proximal tubules. AQP1 is also expressed by the choroid plexus and various other tissues. It forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
基因名
AQP1
蛋白名
Aquaporin-1
亚基
Homotetramer. Interacts with EPHB2; involved in endolymphproduction in the inner ear (By similarity).
亚细胞定位
Membrane; Multi-pass membrane protein.
组织特异性
Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.
相似性
Belongs to the MIP/aquaporin (TC 1.A.8) family.
功能
Forms a water-specific channel that provides the plasmamembranes of red cells and kidney proximal tubules with highpermeability to water, thereby permitting water to move in thedirection of an osmotic gradient.