The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
基因名
S100A4
蛋白名
Protein S100-A4
亚基
Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode.
组织特异性
Ubiquitously expressed.
相似性
Belongs to the S-100 family.
Contains 2 EF-hand domains.