CD33 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-60920R

重组兔单抗

CD33 Recombinant Rabbit mAb

CD33重组兔单抗

CD33rSiglec; SIGLEC-3; SIGLEC3; p67; gp67; CD33_HUMAN; CD33; Sialic acid-binding Ig-like lectin 3 (Siglec-3); CD33_MOUSE; CD33 molecule; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3

Rabbit

A synthesized peptide derived from human CD33: 1-70/364

IgG

Liquid

affinity purified by Protein A

Recombinant

14H11

37 kDa

60 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD33(Siglec-3)也是急性淋巴细胞白血病抗原,细胞表面跨膜糖蛋白.CD33表达于早期B淋巴细胞,某些粒性白细胞,骨髓基质细胞,部分上皮组织及其起源的肿瘤细胞中也有表达.主要应用于某些恶性淋巴瘤和白血病的分型.

Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

CD33

Myeloid cell surface antigen CD33

Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.

Cell membrane; Single-pass type I membrane protein.

Monocytic/myeloid lineage cells.

Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11.
Phosphorylation of Tyr-358 is involved in binding to PTPN6.

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).