MCSF Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF | Bioss

bsm-61014R

重组兔单抗

MCSF Recombinant Rabbit mAb

巨噬细胞克隆刺激因子重组兔单抗

CSF-1; MCSF; PG-M-CSF; BAP025; Csfm; Mhdabap25; op; CSF1_HUMAN; CSF1; M-CSF; Lanimostim; Proteoglycan macrophage colony-stimulating factor (PG-M-CSF); CSF1_MOUSE; CSF1_RAT; colony stimulating factor 1; colony stimulating factor 1 (macrophage); macrophage colony stimulating factor 1

Rabbit

A synthesized peptide derived from human CSF 1: 55-105/554

IgG

Liquid

affinity purified by Protein A

Recombinant

6D7

60 kDa

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

M-CSF是促使造血细胞分化成粒细胞与巨噬细胞克隆的重要细胞因子,对正常血细胞的形成与造血细胞 的存活、分化、正常造血功能 的维持具有重要作用,直接与间接增加lak细胞的活性,在人体 的细胞因子网络中占有重要 的地位,目前广泛应用于化.放疗 的辅助治疗中。
目前研究主要应用在免疫缺陷性疾病及病毒性疾病：慢性肝病,尤其是与病毒相关的疾病,因其发病过程涉及免疫细胞与造血系统,有可能成为gm-csf(粒细胞-巨噬细胞克隆刺激因子)应用的新领域。人和小鼠天然M-CSF为糖蛋白，由二硫键连接的同源双体，分子量40～90kDa。人和小鼠M-CSF分子这个区域结构高度保守，其同源性达80％。

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

CSF1

Macrophage colony-stimulating factor 1

Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

Cell membrane; Single-pass membrane protein. Processed macrophage colony-stimulating factor 1: Secreted, extracellular space.

N-glycosylated. The predominant soluble form is a chondroitin sulfate-containing proteoglycan.

Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.