This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
基因名
AQP4
蛋白名
Aquaporin-4
亚基
Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1.
亚细胞定位
Membrane; Multi-pass membrane protein.
组织特异性
Brain, muscle, heart, kidney, lung, and trachea.
相似性
Belongs to the MIP/aquaporin (TC 1.A.8) family.
功能
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.