PTGER2 Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF | Bioss

bsm-61050R

重组兔单抗

PTGER2 Recombinant Rabbit mAb

列腺素E2受体2重组兔单抗

COX-2; EP2; Ptgerep2; Ptger-ep2; PE2R2_HUMAN; PTGER2; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostanoid EP2 receptor; PE2R2_MOUSE; PE2R2_RAT; prostaglandin E receptor 2; prostaglandin E receptor 2 (subtype EP2), 53kD; prostaglandin E receptor 2 (subtype EP2), 53kDa

Rabbit

A synthesized peptide derived from human PTGER2: 320-358/358

IgG

Liquid

affinity purified by Protein A

Recombinant

2F16

40 kDa

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. Prostaglandin E2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo Prostaglandin E2 induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.

PTGER2

Prostaglandin E2 receptor EP2 subtype

Cell membrane; Multi-pass membrane protein.

Placenta and lung.

Belongs to the G-protein coupled receptor 1 family.

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.