Leptin Receptor Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

Name: 瘦素受体重组兔单抗（Leptin Receptor Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-61055R
Availability: InStock

Rrmab^?兔单抗

2026-07-01~2026-08-31，AB2607A 京东卡2026-07-01~2026-08-31，AB2607B 豪礼卡

一键复制说明书

货号：bsm-61055R

产品详情

概述

产品编号

bsm-61055R

产品类型

重组兔单抗

英文名称

Leptin Receptor Recombinant Rabbit mAb

中文名称

瘦素受体重组兔单抗

英文别名

CD295; LEP-R; LEPRD; OB-R; OBR; B219; LEPROT; Leprb; Modb1; OB-RGRP; db; diabetes; obese-like; obl; Fa; LEPR_HUMAN; LEPR; HuB219; OB receptor (OB-R); LEPR_MOUSE; LEPR_RAT; leptin receptor

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human Leptin receptor: 1050-1095

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

18C15

理论分子量

126 kDa

检测分子量

150 kDa

储存液

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

SWISS

P48357

Gene ID

3953

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 3953 Human

Entrez Gene : 16847 Mouse

Entrez Gene : 24536 Rat

Omim : 601007 Human

SwissProt : P48357 Human

SwissProt : P48356 Mouse

SwissProt : Q62959 Rat

Unigene : 23581 Human

Unigene : 723178 Human

Unigene : 259282 Mouse

Unigene : 9891 Rat

产品介绍

Leptin是一种分子量为16kDa的脂肪组织源激素，由脂肪细胞分泌的，具有强亲水性，以单体形式存在于血浆中。
Leptin 具有广泛的生物学效应，作用于下丘脑，调节食欲、能量代谢及体重。Leptin 还可能作为脂肪-胰岛内分泌轴一部分，参与胰岛素分泌的调节。Leptin receptor (OB-R)是与gp130最密切相关的信号转导的共同成分,属1类细胞因子超家族，下丘脑有丰富的Leptin receptor，在其它部位也有分布，但水平较低：如胰岛素B细胞；脉络丛；肝、肺、心、肾、睾丸、淋巴细胞和脂肪细胞中。
人类存在四个异性体，均为单跨膜受体。其中OB-Rb在胞内结构域最长，是唯一能进行信号传导并调节热量摄入和能量消耗的异性体,分子量为132kDa。

背景资料

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

基因名

LEPR

蛋白名

Leptin receptor

亚基

On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits LRb signaling.

亚细胞定位

Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable). Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.

组织特异性

Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.

翻译后修饰

On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.

相似性

Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 4 fibronectin type-III domains.
Contains 1 Ig-like (immunoglobulin-like) domain.

功能

Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).