PGP9.5 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

Name: 神经细胞胞浆蛋白9.5重组兔单抗（PGP9.5 Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-41257R
Availability: InStock

Rrmab^?兔单抗

2026-07-01~2026-08-31，AB2607A 京东卡2026-07-01~2026-08-31，AB2607B 豪礼卡

一键复制说明书

货号：bsm-41257R

产品详情

概述

产品编号

bsm-41257R

产品类型

重组兔单抗、mIHC精品抗体

英文名称

PGP9.5 Recombinant Rabbit mAb

中文名称

神经细胞胞浆蛋白9.5重组兔单抗

英文别名

HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; SPG79; SPG79A; UCHL-1; Uch-L1; gad; UCHL1_HUMAN; UCHL1; Neuron cytoplasmic protein 9.5; PGP 9.5 (PGP9.5); Ubiquitin thioesterase L1; 3.4.19.12; UCHL1_MOUSE; UCHL1_PIG; UCHL1_RAT; ubiquitin C-terminal hydrolase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin thiolesterase

抗体来源

Rabbit

免疫原

Recombinant human UCHL1 protein

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

18C19

理论分子量

25 kDa

检测分子量

25 kDa

浓度

1mg/ml

储存液

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

SWISS

P09936

Gene ID

7345

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 7345 Human

Entrez Gene : 22223 Mouse

Entrez Gene : 396637 Pig

Entrez Gene : 29545 Rat

SwissProt : P09936 Human

SwissProt : Q9R0P9 Mouse

SwissProt : Q6SEG5 Pig

SwissProt : Q00981 Rat

产品介绍

该抗原是一种神经特异性蛋白，广泛分布于中枢与外周神经系统的神经元和神经纤维、神经内分泌细胞、肾小管段、睾丸精原细胞、Leydig细胞、卵细胞以及妊娠与非妊娠黄体内的某些细胞。用于标记神经元，对研究几种人慢性神经变性性疾病中广泛存在的细胞包涵体特征较有意义。

背景资料

catalyzes the hydrolysis of ubiquitin carboxy-terminal thiolesters to form ubiquitin and a thiol; may play a role in neuropathic pain [RGD].
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.

基因名

UCHL1

蛋白名

Ubiquitin carboxyl-terminal hydrolase isozyme L1

亚基

Monomer. Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.

亚细胞定位

Cytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain.

组织特异性

Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.

翻译后修饰

O-glycosylated.

疾病

Defects in UCHL1 are the cause of Parkinson disease type 5 (PARK5) [MIM:613643]; also known as Parkinson disease autosomal dominant 5. PARK5 is a complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.

相似性

Belongs to the peptidase C12 family.

功能

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.