phospho-GSK3 Alpha + Beta (Tyr279+Tyr216) Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-54505R

磷酸化抗体、重组兔单抗

phospho-GSK3 Alpha + Beta (Tyr279+Tyr216) Recombinant Rabbit mAb

磷酸化糖原合酶激酶3α/β重组兔单抗

2700086H06Rik; GSK3A_HUMAN; GSK3A; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; 2.7.11.26; GSK3A_MOUSE; GSK3A_RAT; Factor A (FA); glycogen synthase kinase 3 alpha; GSK3 alpha & beta (phospho-Y279/Y216); p-GSK3 alpha & beta; phospho-GSK3 alpha & beta; p-GSK3A & p-GSK3B; GSK3 alpha & beta (phospho-Tyr279/Tyr216); 7330414F15Rik; 8430431H08Rik; GSK-3; GSK-3beta; GSK3; GSK3B_HUMAN; GSK3B; GSK-3 beta; Serine/threonine-protein kinase GSK3B; GSK3B_MOUSE

Rabbit

KLH conjugated Synthesised phosphopeptide derived from human GSK-3 Beta around the phosphorylation site of Tyr216

IgG

Liquid

affinity purified by Protein A

Recombinant

5G8

47/51 kDa

47,51 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

组成性活性蛋白激酶，通过磷酸化和失活糖原合成酶（GYS1或GYS2）、CTNNB1/β连环蛋白、APC和AXIN1，在激素控制葡萄糖稳态、Wnt信号传导和转录因子及微管的调节中作为负调节因子。它的大多数底物需要启动磷酸化。通过磷酸化和抑制GYS1活性从而促进糖原合成的胰岛素调节。调节肝脏的糖原代谢，而不是肌肉。也可能通过调节转录因子的激活来介导胰岛素抵抗的发展。在Wnt信号中，调节核CTNNB1/β连环蛋白的水平和转录活性。促进淀粉样前体蛋白（APP）的加工和阿尔茨海默病APP源性淀粉样斑块的形成。可能参与胰腺β细胞复制的调控。也是建立神经元极性和轴突生长所必需的。

GSK3A

Glycogen synthase kinase-3 alpha

Monomer. Interacts with ARRB2. Interacts with AXIN1 and CTNNB1/beta-catenin.

Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Contains 1 protein kinase domain.

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.