API2/BIRC3 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF,IP | Bioss

bsm-61124R

重组兔单抗

API2/BIRC3 Recombinant Rabbit mAb

凋亡抑制因子2重组兔单抗

AIP1; API2; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; MIHC; RNF49; c-IAP2; Api1; HIAP2; IAP1; IAP2; MIAP1; MIAP2; MIHB; cIAP-1; cIAP-2; cIAP1; Birc2; BIRC3_HUMAN; BIRC3; Apoptosis inhibitor 2 (API2); Cellular inhibitor of apoptosis 2 (C-IAP2); IAP homolog C; Inhibitor of apoptosis protein 1 (hIAP-1 | hIAP1); RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF-signaling complex protein 1; 2.3.2.27; BIRC3_MOUSE; Inhibitor of apoptosis protein 1 (mIAP1); baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing 3; apoptosis inhibitor 2; TNFR2-TRAF signaling complex protein; mammalian IAP homolog C; inhibitor of apoptosis protein 1

Rabbit

A synthesized peptide derived from human BIRC3: 400-450/604

IgG

Liquid

affinity purified by Protein A

Recombinant

6C19

68 kDa

68 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.

BIRC3

Baculoviral IAP repeat-containing protein 3

Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.

Cytoplasm. Nucleus.

Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

Belongs to the IAP family.
Contains 3 BIR repeats.
Contains 1 CARD domain.
Contains 1 RING-type zinc finger.

Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).