p57 Kip2/Cdkn1c Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,IP | Bioss

bsm-61145R

重组兔单抗

p57 Kip2/Cdkn1c Recombinant Rabbit mAb

周期蛋白依赖激酶抑制因子1C重组兔单抗

BWCR; BWS; KIP2; WBS; p57; p57Kip2; CDKI; p57(kip2); CDN1C_HUMAN; CDKN1C; Cyclin-dependent kinase inhibitor p57; CDN1C_MOUSE; E9PTV7_RAT; Q69DC0_RAT; cyclin dependent kinase inhibitor 1C; Beckwith-Wiedemann syndrome; cyclin-dependent kinase inhibitor 1C (p57, Kip2)

Rabbit

A synthesized peptide derived from human p57 Kip2: 45-72

IgG

Liquid

affinity purified by Protein A

Recombinant

4E7

32 kDa

50 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

p57 Kip-2调控周期蛋白依赖蛋白激酶、G1 期, 是细胞周期蛋白依赖性激酶(CDK)的抑制蛋白。它通过调控细胞周期进程，参与肿瘤细胞的增殖、分化与凋亡。在多种肿瘤中均发现p57,kip2表达异常，在某些肿瘤中是一种独立的预后因素，与肿瘤的发生、发展及预后有着密切关系。

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

CDKN1C

Cyclin-dependent kinase inhibitor 1C

Interacts with PCNA.

Nucleus.

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
Defects in CDKN1C are the cause of intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE) [MIM:614732]. A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis.
Note=Defects in CDKN1C are involved in tumor formation.

Belongs to the CDI family.

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.