Cathepsin D Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,IP | Bioss

bsm-61164R

重组兔单抗、mIHC精品抗体

Cathepsin D Recombinant Rabbit mAb

组织蛋白酶D重组兔单抗

CLN10; CPSD; HEL-S-130P; CD; CatD; CATD_HUMAN; CTSD; 3.4.23.5; CATD_MOUSE; cathepsin D; cathepsin D (lysosomal aspartyl protease); ceroid-lipofuscinosis, neuronal 10

Rabbit

A synthesized peptide derived from human Cathepsin D: 360-412/412

IgG

Liquid

affinity purified by Protein A

Recombinant

6D8

45 kDa

45 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

CTSD

Cathepsin D

Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Expressed in the aorta extrcellular space (at protein level).

N- and O-glycosylated.

Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10); also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.

Belongs to the peptidase A1 family.

Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.