Somatostatin Receptor 2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,IP | Bioss

bsm-61177R

重组兔单抗、mIHC精品抗体

Somatostatin Receptor 2 Recombinant Rabbit mAb

生长抑素受体2重组兔单抗

SST2; SRIF-1; SS2R; SSTR-2; Smstr-2; Smstr2; SSR2_HUMAN; SSTR2; SS-2-R; SS2-R; SSR2_MOUSE; SSR2_RAT; somatostatin receptor 2

Rabbit

A synthesized peptide derived from human SSTR2: 311-369

IgG

Liquid

affinity purified by Protein A

Recombinant

8H1

41 kDa

70 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SSTR2的表达在肿瘤的分布、发生和发展中起重要作用。目前主要用于肿瘤方面的研究。

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.

SSTR2

Somatostatin receptor type 2

The C-terminus interacts with SHANK1 PDZ domain.

Cell membrane; Multi-pass membrane protein.

Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.

Belongs to the G-protein coupled receptor 1 family.

Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.