HSP60 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-61183R

重组兔单抗、mIHC精品抗体

HSP60 Recombinant Rabbit mAb

热休克蛋白-60/groEL重组兔单抗

CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HuCHA60; SPG13; 60kDa; HSP-65; Hspd1-30p; CH60_MESAU; HSPD1; 60 kDa chaperonin; Chaperonin 60 (CPN60); Heat shock protein 60 (HSP-60 | Hsp60); Mitochondrial matrix protein P1; 5.6.1.7; CH60_HUMAN; Heat shock protein family D member 1; P60 lymphocyte protein; CH60_MOUSE; CH60_RAT; heat shock protein family D (Hsp60) member 1; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); heat shock 60kDa protein 1 (chaperonin)

Rabbit

A synthesized peptide derived from human Hsp60: 420-460

IgG

Liquid

affinity purified by Protein A

Recombinant

9A8

61 kDa

60 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信号传导（Signaling Intermediates）
HSP60是一类进化上高度保守的蛋白质家族.生理状态时协助多肽或蛋白质的正确转位、折叠和装配,起"分子伴侣"的作用;在应激状态下,HSP60过表达或异位表达,作为一种自身抗原被免疫系统识别,诱发机体的保护性免疫应答,也可作为一种信号分子,在信号转导中发挥作用.
该蛋白与肿瘤的发生、增殖及分化有关，主要用于舌鳞癌、结肠癌、胰腺癌和乳腺癌的研究，近年来研究证实HSP60在自身免疫性疾病、传染病、动脉粥样硬化及慢性感染的发病中均发挥重要的作用。
HSP-60热休克蛋白-蛋白质折叠过程的引导因子

分子伴侣是一种引导蛋白质正确折叠的蛋白质。当蛋白质折叠时，它们能保护蛋白质分子免受其它蛋白质的干扰。很多分子伴侣属于热休克蛋白（例如HSP-60），它们在细胞受热时大量合成。热激可导致蛋白质稳定性降低，增加错误折叠的几率，因此在受到热刺激时，细胞中的蛋白质需要更多热休克蛋白的帮助。
HSP-60是一种典型的分子伴侣，它可以为正在折叠的蛋白质提供一个附着环境，从而起到保护折叠过程的作用。

Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

HSPD1

60 kDa heat shock protein, mitochondrial

Interacts with HRAS (By similarity). Interacts with HBV protein X and HTLV-1 protein p40tax. Interacts with ATAD3A.

Mitochondrion matrix.

Spastic paraplegia autosomal dominant 13 (SPG13) [MIM:605280]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry.
Leukodystrophy, hypomyelinating, 4 (HLD4) [MIM:612233]: A severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurs within the first two decades of life. Note=The disease is caused by mutations affecting the gene represented in this entry.

Belongs to the chaperonin (HSP60) family.

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.