MyD88 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,ICC/IF,IF | Bioss

bsm-61269R

重组兔单抗

MyD88 Recombinant Rabbit mAb

髓样分化蛋白重组兔单抗

IMD68; MYD88D; WM1; MYD88_HUMAN; MYD88; MYD88_MOUSE; MYD88_RAT; MYD88 innate immune signal transduction adaptor; myeloid differentiation primary response gene (88); myeloid differentiation primary response 88; TLR adaptor MYD88

Rabbit

A synthesized peptide derived from human MyD88: 1-48

IgG

Liquid

affinity purified by Protein A

Recombinant

3C9

33 kDa

33 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MyD88是天然免疫中的调控分子,可能在感染、炎症、免疫等病理生理过程中具有更广泛的生物学功能,　MyD88蛋白是由Toll样受体介导的先天免疫应答反应中重要的胞浆接头蛋白，由它参与构成的信号级联最终引起NF-kB依赖性信号通路的活化。

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

MYD88

Myeloid differentiation primary response protein MyD88

Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1 (By similarity). Interacts with BMX, IL1RL1 and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. May interact with PIK3AP1 (By similarity). Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression.

Cytoplasm.

Ubiquitous.

Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.

Contains 1 death domain.
Contains 1 TIR domain.

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.