MGMT Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-61358R

重组兔单抗

MGMT Recombinant Rabbit mAb

O6甲基鸟嘌呤DNA甲基转移酶重组兔单抗

MGMT_HUMAN; MGMT; 6-O-methylguanine-DNA methyltransferase (MGMT); O-6-methylguanine-DNA-alkyltransferase; 2.1.1.63; O-6-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase

Rabbit

A synthesized peptide derived from human MGMT: 1-45/207

IgG

Liquid

affinity purified by Protein A

Recombinant

3F8

22 kDa

20 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

MGMT

Methylated-DNA--protein-cysteine methyltransferase

Nucleus.

Belongs to the MGMT family.

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.