Jab1/COPS5 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,IP | Bioss

bsm-61721R

重组兔单抗

Jab1/COPS5 Recombinant Rabbit mAb

Jun激活区域-连接蛋白1重组兔单抗

CSN5; JAB1; MOV-34; SGN5; Mov34; CSN5_HUMAN; COPS5; Signalosome subunit 5; Jun activation domain-binding protein 1; 3.4.-.-; CSN5_MOUSE; Kip1 C-terminus-interacting protein 2; Kic2; COP9 signalosome subunit 5; COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5; COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)

Rabbit

A synthesized peptide derived from human COPS5: 10-80

IgG

Liquid

affinity purified by Protein A

Recombinant

1A9

38 kDa

37 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录调节因子（Transcriptin Regulators）
Jab1是一种多功能蛋白质,能与多种蛋白发生相互作用,调控多种细胞内信号转导通路。JAB1也可增强多种转录因子的活性.

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.

COPS5

COP9 signalosome complex subunit 5

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Interacts with IFIT3. Interacts with BRSK2.

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is diminished in the presence of IFIT3.

Belongs to the peptidase M67A family. CSN5 subfamily.
Contains 1 MPN (JAB/Mov34) domain.

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.