ADAR1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-61724R

重组兔单抗

ADAR1 Recombinant Rabbit mAb

双链RNA腺苷酸脱氨基酶重组兔单抗

ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136; Adar1p110; Adar1p150; mZaADAR; DSRAD_HUMAN; ADAR; 136 kDa double-stranded RNA-binding protein (p136); Interferon-inducible protein 4 (IFI-4); 3.5.4.37; DSRAD_MOUSE; RNA adenosine deaminase 1; adenosine deaminase RNA specific; interferon-induced protein 4; Double-stranded RNA-specific adenosine deaminase

Rabbit

A synthesized peptide derived from human ADAR1: 200-250

IgG

Liquid

affinity purified by Protein A

Recombinant

9A11

136 kDa

160 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ADAR腺苷脱氨酶是一种存在于嘌呤新陈代谢的酶，属于巯基酶。

Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity.

ADAR

Double-stranded RNA-specific adenosine deaminase

Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90.

Cytoplasm. Nucleus, nucleolus. Isoform 1: Cytoplasm. Note=Found predominantly in cytoplasm but appears to shuttle between the cytoplasm and nucleus. Isoform 5: Nucleus, nucleolus.

Ubiquitously expressed, highest levels were found in brain and lung.

Sumoylation reduces RNA-editing activity.

Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria (DSH) [MIM:127400]; also known as reticulate acropigmentation of Dohi. DSH is a pigmentary genodermatosis of autosomal dominant inheritance characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the dorsal parts of the hands and feet.

Contains 1 A to I editase domain.
Contains 2 DRADA repeats.
Contains 3 DRBM (double-stranded RNA-binding) domains.

Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.