IMP3 Recombinant Rabbit mAb (一抗) - WB,IP,Flow-Cyt,IHC-P,IHC-F,IF | Bioss

bsm-61766R

重组兔单抗、mIHC精品抗体

IMP3 Recombinant Rabbit mAb

胰岛素样生长因子2mRNA结合蛋白3重组兔单抗

CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3; 2610101N11Rik; Koc13; Neilsen; mimp3; Ab2-255; RGD1306512; IF2B3_HUMAN; IGF2BP3; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer (hKOC); VICKZ family member 3; IF2B3_MOUSE; mIMP-3; insulin like growth factor 2 mRNA binding protein 3; insulin-like growth factor 2 mRNA binding protein 3; IGF II mRNA binding protein 3; cancer/testis antigen 98

Rabbit

A synthesized peptide derived from human IMP 3: 1-200

IgG

Liquid

affinity purified by Protein A

Recombinant

3D10

64 kDa

65 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IGF2BP3是一种可以与胰岛素样生长因子(IGFs)结合的分泌性蛋白,其通过IGFs调节细胞的生长、分化、凋亡、黏附和运动,IGF2BP3与IGFs结合可以调节IGFs与IGF2型受体间的相互作用,改变其促有丝分裂效应、凋亡抑制效应和促细胞运动作用。

RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage.

IGF2BP3

Insulin-like growth factor 2 mRNA-binding protein 3

Homodimer and multimer. Interacts with IGF2BP1.

Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.

Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

Belongs to the RRM IMP/VICKZ family.
Contains 4 KH domains.
Contains 2 RRM (RNA recognition motif) domains.

RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA.