KDM5A Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF,IP | Bioss

bsm-61779R

重组兔单抗

KDM5A Recombinant Rabbit mAb

组蛋白去甲基化酶JARID1A重组兔单抗

KDM5A_HUMAN; KDM5A; Histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; Retinoblastoma-binding protein 2 (RBBP-2); [histone H3]-trimethyl-L-lysine(4) demethylase 5A; 1.14.11.67; JARID1A; RBBP2; RBP2; KDM5A_MOUSE; lysine demethylase 5A; retinoblastoma-binding protein 2; Jumonji, AT rich interactive domain 1A (RBBP2-like); jumonji, AT rich interactive domain 1A; lysine (K)-specific demethylase 5A

Rabbit

A synthesized peptide derived from human KDM5A: 1400-1690

IgG

Liquid

affinity purified by Protein A

Recombinant

4G2

192 kDa

200 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.

KDM5A

Lysine-specific demethylase 5A

Nucleus > nucleolus. Occupies promoters of genes involved in RNA metabolism and mitochondrial function.

Belongs to the JARID1 histone demethylase family.
Contains 1 ARID domain.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 3 PHD-type zinc fingers.

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12.