DCP1A Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
Rrmab?兔单抗
货号：bsm-61822R
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概述
产品编号
bsm-61822R
产品类型
重组兔单抗
英文名称
DCP1A Recombinant Rabbit mAb
中文名称
脱帽酶1A重组兔单抗
英文别名
HSA275986; Nbla00360; SMAD4IP1; SMIF; 1110066A22Rik; 4930568L04Rik; D14Ertd817e; Mitc1; RGD1561298; DCP1A_HUMAN; DCP1A; Smad4-interacting transcriptional co-activator; Transcription factor SMIF; 3.6.1.62; DCP1A_MOUSE; MAD homolog 4-interacting transcription coactivator 1; decapping mRNA 1A; DCP1 decapping enzyme homolog A (S. cerevisiae)
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human DCP1A: 500-582
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8G6
理论分子量
63 kDa
检测分子量
70 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay.Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP.Contributes to the transactivation of target genes after stimulation by TGFB1.
基因名
DCP1A
蛋白名
mRNA-decapping enzyme 1A
亚基
Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with PNRC2. Interacts with DDX17 in an RNA-independent manner. Interacts with ZC3HAV1.
亚细胞定位
Cytoplasm, P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies. Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.
组织特异性
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
相似性
Belongs to the DCP1 family.
功能
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| IHC-P | Human, Mouse | Rat | 1:50-200 |
| IHC-F | Human, Mouse | Rat | 1:50-200 |
| IF | Human, Mouse | Rat | 1:50-200 |
| Flow-Cyt | Human | Mouse, Rat | 1:50-100 |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat)
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