Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. Cannot reduce phosphatidycholine hydroperoxide.
基因名
GPX2
蛋白名
Glutathione peroxidase 2
亚基
Homotetramer.
亚细胞定位
Cytoplasm. Mainly cytoplasmic.
组织特异性
Mostly in liver and gastrointestinal tract, not found in heart or kidney.
相似性
Belongs to the glutathione peroxidase family.
功能
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.