SIRP Alpha Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-61992R

重组兔单抗

SIRP Alpha Recombinant Rabbit mAb

信号调节蛋白α重组兔单抗

BIT; CD172A; MFR; MYD-1; MYD1; P84; PTPNS1; SHPS1; SIRP; Idd13.2; SHP-1; SHPS-1; SHPS1_HUMAN; SIRPA; SHP substrate 1; Brain Ig-like molecule with tyrosine-based activation motifs (Bit); CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1 (Sirp-alpha-1); Signal-regulatory protein alpha-2 (Sirp-alpha-2); Signal-regulatory protein alpha-3 (Sirp-alpha-3); SHPS1_MOUSE; Signal-regulatory protein alpha-1 (Sirp-alpha-1 | mSIRP-alpha1); SHPS1_RAT; Macrophage membrane protein MFP150; signal regulatory protein alpha; protein tyrosine phosphatase, non-receptor type substrate 1; signal-regulatory protein alpha

Rabbit

A synthesized peptide derived from human SHP substrate 1: 395-495

IgG

Liquid

affinity purified by Protein A

Recombinant

19H5

55 kDa

60-120 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SIRPA

Tyrosine-protein phosphatase non-receptor type substrate 1

Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.

Membrane; Single-pass type I membraneprotein.

Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

N-glycosylated.
Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF.
Dephosphorylated by PTPN11.

Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.