Scramblase 1 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF,IP | Bioss

bsm-62122R

重组兔单抗

Scramblase 1 Recombinant Rabbit mAb

磷脂争夺酶1重组兔单抗

MMTRA1B; PLS1_HUMAN; PLSCR1; PL scramblase 1; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; Mg(2+)-dependent nuclease; phospholipid scramblase 1

Rabbit

A synthesized peptide derived from human Phospholipid scramblase 1: 20-55

IgG

Liquid

affinity purified by Protein A

Recombinant

6E12

35 kDa

35 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface.

PLSCR1

phospholipid scramblase 1

Membrane.

Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.

Known to be palmitoylated at one, yet undefined, site.

Belongs to the phospholipid scramblase family.

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.