LGR6 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-62179R

重组兔单抗

LGR6 Recombinant Rabbit mAb

G蛋白偶联受体6重组兔单抗

GPCR; VTS20631; A530037C04Rik; D830026M09; RGD1560339; LGR6_HUMAN; LGR6; LGR6_MOUSE; leucine rich repeat containing G protein-coupled receptor 6

Rabbit

A synthesized peptide derived from human LGR6: 850-967

IgG

Liquid

affinity purified by Protein A

Recombinant

12H9

104 kDa

104 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

LGR6

Leucine-rich repeat-containing G-protein coupled receptor 6

Cell membrane.

Phosphorylated upon DNA damage, probably by ATM or ATR.

Belongs to the G-protein coupled receptor 1 family.
Contains 15 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

Orphan receptor.