Fibrinogen alpha chain Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP | Bioss

bsm-62182R

重组兔单抗

Fibrinogen alpha chain Recombinant Rabbit mAb

纤维蛋白肽A重组兔单抗

AMYLD2; Fib2; HEL-S-78p; FIBA_HUMAN; FGA;

Rabbit

A synthesized peptide derived from human Fibrinogen alpha chain: 750-800/866

IgG

Liquid

affinity purified by Protein A

Recombinant

8F2

9001-32-5

95 kDa

105 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CAS号：9001-32-5
分子量：
α-chain 63.5 kDa;
β-chain 56 kDa;
γ chain 47 kDa (about 4% carbohydrate content);
soluble dimer 340 kDa;
MDL：MFCD00131060
级别：BR
蛋白含量：Type I-S, 65-85% protein (≥75% of protein is clottable)
来源：牛
外观：白色粉末
用途：细胞培养，合适哺乳动物。
纤维蛋白原已应用于外科和大规模创伤患者的止血治疗研究。这些研究表明，与使用新鲜冷冻血浆相比，纤维蛋白原在止血方面可能更为优越。

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots.

FGA/FGB/FGG

Fibrinogen alpha chain

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

Secreted.

Plasma.

The alpha chain is not glycosylated.
Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
Phosphorylation sites are present in the extracellular medium.

Defects in FGA are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
Defects in FGA are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.

Contains 1 fibrinogen C-terminal domain.

Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.