DNA-dependent helicase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability.Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination.
基因名
BRIP1
蛋白名
Fanconi anemia group J protein
亚细胞定位
Nucleus.
相似性
Belongs to the bZIP family. CNC subfamily. Contains 1 BTB (POZ) domain. Contains 1 bZIP domain.
功能
Transcriptional regulator that acts as repressor or activator. Binds, in-vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.