The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations.
基因名
PANX1
蛋白名
Pannexin-1
亚基
Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).
亚细胞定位
Cell membrane. Cell junction > gap junction. Endoplasmic reticulum membrane.
相似性
Belongs to the pannexin family.
功能
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.