PHGDH | 3-PGDH Recombinant Mouse mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

Name: 磷酸甘油酸脱氢酶单克隆抗体（PHGDH | 3-PGDH Recombinant Mouse mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-60570M
Availability: InStock

AB2609A 京东卡

一键复制说明书

货号：bsm-60570M

产品详情

概述

产品编号

bsm-60570M

产品类型

重组小鼠单抗

英文名称

PHGDH | 3-PGDH Recombinant Mouse mAb

中文名称

磷酸甘油酸脱氢酶单克隆抗体

英文别名

3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA; 4930479N23; A10; SERA_HUMAN; PHGDH; 2-oxoglutarate reductase; Malate dehydrogenase; 1.1.1.95; PGDH3; SERA_MOUSE; SERA_RAT; phosphoglycerate dehydrogenase; D-3-phosphoglycerate dehydrogenase

抗体来源

Mouse

亚型

IgG1, Kappa

性状

Liquid

纯化方法

affinity purified by Protein G

克隆类型

Recombinant

克隆号

D12E1

理论分子量

56 kDa

检测分子量

57 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

研究领域

Metabolism > Pathways and Processes > Metabolic signaling pathways > Amino acid metabolism

Neuroscience > Neurology process > Neurogenesis

Signal Transduction > Metabolism > Amino Acids

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 26227 Human

Entrez Gene : 236539 Mouse

Entrez Gene : 58835 Rat

SwissProt : O43175 Human

SwissProt : Q61753 Mouse

SwissProt : O08651 Rat

产品介绍

催化3-磷酸-D-甘油酯可逆氧化为3-磷酸丙酮酸，这是L-丝氨酸磷酸化生物合成途径的第一步。还催化2-羟基戊二酸可逆氧化为2-酮戊二酸和（S）-苹果酸可逆氧化为草酰乙酸。

背景资料

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

基因名

PHGDH

蛋白名

D-3-phosphoglycerate dehydrogenase

亚基

Homotetramer

疾病

Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) . It is characterized by congenital microcephaly, psychomotor retardation, and seizures.

相似性

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

功能

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.