SRD5A2 Recombinant Rabbit mAb (一抗) - WB,IP | Bioss

bsm-62269R

重组兔单抗

SRD5A2 Recombinant Rabbit mAb

类固醇5α还原酶2重组兔单抗

5ART2; S5AR 2; ST5AR2; S5A2_HUMAN; SRD5A2; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2 (S5AR 2); Type II 5-alpha reductase; 1.3.1.22; Q3UTZ9_MOUSE; S5A2_MOUSE; S5A2_PIG; S5A2_RAT; steroid 5 alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Rabbit

A synthesized peptide derived from human SRD5A2: 1-70/254

IgG

Liquid

affinity purified by Protein A

Recombinant

5H4

28 kDa

25 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

SRD5A2

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential).

Expressed in high levels in the prostate and many other androgen-sensitive tissues.

Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.

Belongs to the steroid 5-alpha reductase family.

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.