Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure.Specifically recognizes and binds proteins with a RFXV motif.
基因名
STK39
蛋白名
STE20/SPS1-related proline-alanine-rich protein kinase
亚基
The phosphorylated form forms a complex with WNK2 (By similarity).
亚细胞定位
Cytoplasm. Nucleus. Nucleus when caspase-cleaved.
组织特异性
Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.
翻译后修饰
Phosphorylated at Ser-309 by PRKCQ.
相似性
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 protein kinase domain.
功能
May act as a mediator of stress-activated signals.