Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
基因名
DCAF13
蛋白名
DDB1-and CUL4-associated factor 13
亚基
Interacts with DDB1.
亚细胞定位
Nucleus, nucleolus (By similarity).
相似性
Contains 7 WD repeats.
功能
Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.