GOT1 | cAST Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss

bsm-63078R

重组兔单抗

GOT1 | cAST Recombinant Rabbit mAb

谷草转氨酶重组兔单抗

AATC_HUMAN; GOT1; cAspAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic (cCAT); Glutamate oxaloacetate transaminase 1; Transaminase A; 2.6.1.1; 2.6.1.3; AST; AST1; ASTQTL1; GIG18; SGOT; cCAT; glutamic-oxaloacetic transaminase 1; glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); glutamic-oxaloacetic transaminase 1, soluble; aspartate aminotransferase 1; aspartate transaminase 1

Rabbit

A synthesized peptide derived from human GOT1: 150-230/413

IgG

Liquid

affinity purified by Protein A

Recombinant

2F11

46 kDa

41 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Aspartate Aminotransferase [Glutamate oxaloacetate transaminase] is a ubiquitous pyridoxal phosphate-dependent enzyme which exists in both mitochondrial and cytosolic forms. The enzyme plays an important role in amino acid metabolism and in the urea and tricarboxylic acid cycles. The 2 isoenzymes are homodimeric. In liver about 80% of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic. Although the mitochondrial and soluble forms of GOT are coded by different chromosomes, the 2 show close homology in amino acid sequence and were presumably derived from a common ancestral gene.

GOT1

Aspartate aminotransferase, cytoplasmic

Homodimer.

Cytoplasm.

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.