NFE2L2 | NRF2 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

AB2609A 京东卡组化荧光优选(赠品)
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货号：bs-1074R
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概述

产品编号
bs-1074R
英文名称
NFE2L2 | NRF2 Rabbit pAb
中文名称
核因子2相关因子2抗体
英文别名
HEBP1; IMDDHH; NRF2; Nrf-2; NF2L2_HUMAN; NFE2L2; NF-E2-related factor 2; NFE2-related factor 2; Nuclear factor, erythroid derived 2, like 2; NFE2 like bZIP transcription factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid 2 like 2
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Nrf2: 401-500/605
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
68 kDa
检测分子量
90-110 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域

Cardiovascular > Heart > Cardiac metabolism

Cell Biology > Other Antibodies > Oxidative Stress

Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies

Epigenetics and Nuclear Signaling > Transcription > Other factors

Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism > Molecular processes > Mitochondrial transcription

Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial Biogenesis

Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress

SWISS
Q16236
Gene ID
4780
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 4780 Human

Omim : 600492 Human

SwissProt : Q16236 Human

产品介绍
转录调节因子（Transcriptin Regulators） 核细胞系因子2相关因子Nrf2，是一种对氧化还原反应敏感的转录因子，可以通过正向促进基因的表达，来转录翻译产生一些抗氧化物，行使着异化解毒的酶类和药物的高效外排泵作用。
有学者认为：核因子2相关因子2蛋白在保护细胞免受环境毒性物质影响方面发挥着极其重要的作用，它指导某些基因促进细胞的防御工事，同时也刺激某些重要解毒酶对毒性物质，如黄曲霉素的解毒和排毒作用。
背景资料
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor which regulates the expression of many detoxification and antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar (CNC-bZIP) subfamily of basic /leucine zipper (bZIP) transcription factors.
基因名
NFE2L2
蛋白名
Nuclear factor erythroid 2-related factor 2
亚基
Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.
亚细胞定位
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
组织特异性
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
翻译后修饰
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
相似性
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.
功能
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
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产品应用

应用 已检合格种属 预测种属 推荐稀释比例
WB Human, Mouse Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse 1:1000-5000
IHC-P Human, Mouse, Rat Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse 1:200-1000
IHC-F Human, Mouse, Rat Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse 1:200-1000
IF Human, Mouse, Rat Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse 1:200-1000
Flow-Cyt Human Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse 1μg/Test
ICC/IF Human Mouse, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse 1:100-500

交叉反应

交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse)

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