NFX1 Rabbit pAb (一抗) | Bioss
货号：bs-8377R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bs-8377R
英文名称
NFX1 Rabbit pAb
中文名称
核转录因子X盒结合蛋白1抗体
英文别名
NFX2; TEG-42; Tex42; 1300017N15Rik; 3000003M19Rik; NFX.1; NFX1_HUMAN; NFX1; Nuclear transcription factor, X box-binding protein 1; 2.3.2.-; NFX1_MOUSE; m-Nfx.1; nuclear transcription factor, X-box binding 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human NFX1: 881-980/1120
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
124 kDa
检测分子量
124 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. It may play a role in the inflammatory response, regulating its duration by limiting the period in which class II MHC molecules are induced by IFN gamma. The RING type zinc finger domain interacts with an ubiquitin conjugating enzyme (E2) and facilitates ubiquitination.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
相关产品
暂无相关产品
靶标
基因名
NFX1
蛋白名
Transcriptional repressor NF-X1
亚基
Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4.
亚细胞定位
Nucleus.
翻译后修饰
Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1 is not polyubiquitinated.
相似性
Belongs to the NFX1 family.
Contains 8 NF-X1-type zinc fingers.
Contains 1 R3H domain.
Contains 1 RING-type zinc finger.
Contains 8 NF-X1-type zinc fingers.
Contains 1 R3H domain.
Contains 1 RING-type zinc finger.
功能
Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
同靶标产品
相关文献
提示: 发表研究结果有使用 bs-8377R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。